1. Round | 21/01/2022 | H&H Export Sébaco | - | Real Estelí FC | 4:4 | ||||
6. Round | 27/02/2022 | Real Estelí FC | - | Diriangén FC | 1:4 | ||||
11. Round | 20/03/2022 | Real Estelí FC | - | Real Madriz | 4:0 | ||||
12. Round | 03/04/2022 | Managua FC | - | Real Estelí FC | 1:2 | ||||
13. Round | 07/04/2022 | Juventus Managua | - | Real Estelí FC | 0:3 | ||||
14. Round | 11/04/2022 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 |