| 1. Round | 02/08/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 | ||||
| 2. Round | 08/08/2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:0 | ||||
| 5. Round | 29/08/2021 | Club Deportivo Ocotal | - | Real Madriz | 2:1 | ||||
| 7. Round | 13/09/2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 |  |
|||
| 8. Round | 20/09/2021 | Club Deportivo Ocotal | - | UNAN Managua | 1:2 | ||||
| 6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 |
Nicaragua