| 2. Round | 01/08/2021 | Guadalupe | - | AD San Carlos | 1:1 | ||||
| 3. Round | 07/08/2021 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 5. Round | 14/08/2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 6. Round | 18/08/2021 | CS Herediano | - | AD San Carlos | 2:0 | ||||
| 12. Round | 18/09/2021 | LD Alajuelense | - | AD San Carlos | 2:2 | ||||
| 13. Round | 26/09/2021 | AD San Carlos | - | Guadalupe | 4:2 | ||||
| 14. Round | 03/10/2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 | ||||
| 20. Round | 20/11/2021 | AD San Carlos | - | Santos de Guápiles | 2:4 |
Costa Rica