| 1. Round | 20/07/2021 | Alianza Petrolera | - | La Equidad | 1:0 | ||||
| 2. Round | 27/07/2021 | Deportivo Pereira | - | Alianza Petrolera | 0:2 |  |
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| 3. Round | 31/07/2021 | Deportes Tolima | - | Alianza Petrolera | 1:1 | ||||
| 4. Round | 09/08/2021 | Alianza Petrolera | - | Deportivo Pasto | 2:0 | ||||
| 5. Round | 14/08/2021 | Envigado FC | - | Alianza Petrolera | 2:1 | ||||
| 6. Round | 23/08/2021 | Alianza Petrolera | - | Deportivo Cali | 2:3 | ||||
| 9. Round | 12/09/2021 | Santa Fe | - | Alianza Petrolera | 1:1 | ||||
| 11. Round | 25/09/2021 | Once Caldas | - | Alianza Petrolera | 1:1 | ||||
| 12. Round | 04/10/2021 | Alianza Petrolera | - | Jaguares de Córdoba | 1:1 | ||||
| 13. Round | 09/10/2021 | Águilas Doradas | - | Alianza Petrolera | 1:0 | ||||
| 17. Round | 01/11/2021 | América de Cali | - | Alianza Petrolera | 1:1 | ||||
| 18. Round | 06/11/2021 | Alianza Petrolera | - | Atlético Huila | 1:0 | ||||
| 19. Round | 14/11/2021 | Millonarios | - | Alianza Petrolera | 1:1 | ||||
| 20. Round | 21/11/2021 | Alianza Petrolera | - | Atlético Junior | 1:1 |
Colombia