| 1. Round | 10/02/2022 | Deportes Quindío | - | Bogotá FC | 1:0 |  |
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| 1. Round | 24/02/2022 | Bogotá FC | - | Deportes Quindío | 2:2 | ||||
| 2. Round | 04/03/2022 | Deportes Quindío | - | Llaneros FC | 3:0 | ||||
| 2. Round | 17/03/2022 | Llaneros FC | - | Deportes Quindío | 2:0 | ||||
| 3. Round | 01/04/2022 | Once Caldas | - | Deportes Quindío | 0:0 | ||||
| 3. Round | 07/04/2022 | Deportes Quindío | - | Once Caldas | 0:1 |
Colombia