| 1. Round | 26/07/2021 | Unión Magdalena | - | Fortaleza FC | 3:1 |  |
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| 2. Round | 31/07/2021 | Real Santander | - | Unión Magdalena | 3:3 | |
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| 3. Round | 10/08/2021 | Unión Magdalena | - | Cortuluá | 2:0 | ||||
| 5. Round | 21/08/2021 | Boca Juniors de Cali | - | Unión Magdalena | 0:2 | ||||
| 6. Round | 31/08/2021 | Unión Magdalena | - | Real Cartagena | 1:0 |  |
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| 7. Round | 04/09/2021 | Leones FC | - | Unión Magdalena | 3:0 | ||||
| 15. Round | 30/10/2021 | Boyacá Chicó | - | Unión Magdalena | 1:0 |
Colombia