| 1. Round | 26/07/2020 | Club Tijuana | - | Atlas Guadalajara | 3:1 | ||||
| 2. Round | 02/08/2020 | CF América | - | Club Tijuana | 4:0 | ||||
| 3. Round | 07/08/2020 | Club Tijuana | - | UANL Tigres | 0:0 | ||||
| 4. Round | 13/08/2020 | Club Tijuana | - | Atlético San Luis | 0:2 | ||||
| 5. Round | 18/08/2020 | Club León | - | Club Tijuana | 2:1 | ||||
| 6. Round | 24/08/2020 | Club Tijuana | - | Puebla FC | 1:0 | ||||
| 7. Round | 30/08/2020 | Pumas UNAM | - | Club Tijuana | 3:0 | ||||
| 8. Round | 05/09/2020 | Club Tijuana | - | CF Monterrey | 2:1 |  |
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| 9. Round | 10/09/2020 | Mazatlán FC | - | Club Tijuana | 1:0 |  |
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| 10. Round | 14/09/2020 | Club Tijuana | - | Cruz Azul | 1:2 | ||||
| 11. Round | 01/10/2020 | Club Tijuana | - | FC Juárez | 2:1 | ||||
| 13. Round | 05/10/2020 | Club Tijuana | - | Deportivo Guadalajara | 0:0 | |
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| 12. Round | 12/10/2020 | Santos Laguna | - | Club Tijuana | 2:0 | ||||
| 14. Round | 17/10/2020 | Club Necaxa | - | Club Tijuana | 2:0 | ||||
| 15. Round | 25/10/2020 | Deportivo Toluca | - | Club Tijuana | 2:0 | ||||
| 16. Round | 31/10/2020 | Club Tijuana | - | CF Pachuca | 0:2 | ||||
| 17. Round | 09/11/2020 | Gallos Blancos | - | Club Tijuana | 2:2 |
Colombia