| 1. Round | 24/07/2021 | FC Juárez | - | Deportivo Toluca | 1:3 | ||||
| 2. Round | 01/08/2021 | Atlas Guadalajara | - | FC Juárez | 2:0 | ||||
| 3. Round | 07/08/2021 | Deportivo Guadalajara | - | FC Juárez | 2:2 | ||||
| 4. Round | 14/08/2021 | FC Juárez | - | Club Tijuana | 1:1 | ||||
| 5. Round | 19/08/2021 | FC Juárez | - | CF América | 1:2 | ||||
| 6. Round | 23/08/2021 | Club Necaxa | - | FC Juárez | 1:0 | ||||
| 7. Round | 30/08/2021 | Santos Laguna | - | FC Juárez | 2:0 | ||||
| 8. Round | 11/09/2021 | FC Juárez | - | Cruz Azul | 2:1 | ||||
| 9. Round | 18/09/2021 | Club León | - | FC Juárez | 0:1 | ||||
| 14. Round | 22/09/2021 | FC Juárez | - | Atlético San Luis | 1:0 | ||||
| 11. Round | 29/09/2021 | Mazatlán FC | - | FC Juárez | 3:1 |  |
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| 12. Round | 02/10/2021 | FC Juárez | - | CF Monterrey | 3:1 | ||||
| 10. Round | 09/10/2021 | FC Juárez | - | Gallos Blancos | 0:0 | ||||
| 13. Round | 17/10/2021 | Pumas UNAM | - | FC Juárez | 1:0 | ||||
| 15. Round | 25/10/2021 | CF Pachuca | - | FC Juárez | 1:1 | ||||
| 16. Round | 30/10/2021 | FC Juárez | - | Puebla FC | 0:2 | ||||
| 17. Round | 07/11/2021 | UANL Tigres | - | FC Juárez | 3:0 |
Colombia