| 1. Round | 11/07/2022 | Deportes Tolima | - | Independiente Medellín | 1:1 | ||||
| 2. Round | 15/07/2022 | Deportes Tolima | - | Deportivo Cali | 2:0 | ||||
| 3. Round | 19/07/2022 | Unión Magdalena | - | Deportes Tolima | 2:1 |  |
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| 6. Round | 06/08/2022 | Deportes Tolima | - | Jaguares de Córdoba | 2:2 | ||||
| 7. Round | 13/08/2022 | Santa Fe | - | Deportes Tolima | 2:1 | ||||
| 8. Round | 22/08/2022 | Deportes Tolima | - | La Equidad | 1:1 | ||||
| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 | ||||
| 10. Round | 04/09/2022 | Deportes Tolima | - | Cortuluá | 0:0 | ||||
| 11. Round | 10/09/2022 | Patriotas FC | - | Deportes Tolima | 1:1 | ||||
| 14. Round | 26/09/2022 | Deportes Tolima | - | Deportivo Pereira | 1:3 |  |
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| 17. Round | 13/10/2022 | Deportes Tolima | - | Alianza Petrolera | 2:0 | ||||
| 18. Round | 16/10/2022 | Cortuluá | - | Deportes Tolima | 0:1 |
Colombia