| 1. Round | 17/01/2021 | Atlético Junior | - | Independiente Medellín | 1:0 | ||||
| 2. Round | 25/01/2021 | Once Caldas | - | Atlético Junior | 1:2 | ||||
| 6. Round | 14/02/2021 | Envigado FC | - | Atlético Junior | 2:2 | ||||
| 7. Round | 18/02/2021 | Atlético Junior | - | Deportivo Cali | 1:2 |  |
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| 8. Round | 21/02/2021 | Boyacá Chicó | - | Atlético Junior | 2:1 |  |
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| 9. Round | 24/02/2021 | Atlético Junior | - | Millonarios | 2:0 | ||||
| 10. Round | 28/02/2021 | Patriotas FC | - | Atlético Junior | 1:0 | ||||
| 11. Round | 06/03/2021 | Atlético Junior | - | Atlético Bucaramanga | 1:1 | |
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| 15. Round | 27/03/2021 | Atlético Junior | - | Santa Fe | 1:1 | ||||
| 16. Round | 31/03/2021 | Jaguares de Córdoba | - | Atlético Junior | 0:2 | ||||
| 17. Round | 05/04/2021 | Atlético Junior | - | Águilas Doradas | 0:0 | |
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| 18. Round | 11/04/2021 | Deportivo Pasto | - | Atlético Junior | 0:0 |
Argentina