| 2. Round | 25/01/2021 | Once Caldas | - | Atlético Junior | 1:2 | ||||
| 3. Round | 31/01/2021 | Atlético Junior | - | América de Cali | 2:1 | ||||
| 4. Round | 03/02/2021 | La Equidad | - | Atlético Junior | 1:0 | ||||
| 5. Round | 06/02/2021 | Atlético Junior | - | Alianza Petrolera | 2:0 | ||||
| 6. Round | 14/02/2021 | Envigado FC | - | Atlético Junior | 2:2 | ||||
| 7. Round | 18/02/2021 | Atlético Junior | - | Deportivo Cali | 1:2 | ||||
| 8. Round | 21/02/2021 | Boyacá Chicó | - | Atlético Junior | 2:1 | ||||
| 9. Round | 24/02/2021 | Atlético Junior | - | Millonarios | 2:0 |  |
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| 10. Round | 28/02/2021 | Patriotas FC | - | Atlético Junior | 1:0 | ||||
| 11. Round | 06/03/2021 | Atlético Junior | - | Atlético Bucaramanga | 1:1 | ||||
| 12. Round | 15/03/2021 | Atlético Nacional | - | Atlético Junior | 1:0 | ||||
| 13. Round | 20/03/2021 | Atlético Junior | - | Deportivo Pereira | 3:0 | ||||
| 14. Round | 24/03/2021 | Deportes Tolima | - | Atlético Junior | 0:1 | ||||
| 15. Round | 27/03/2021 | Atlético Junior | - | Santa Fe | 1:1 | ||||
| 16. Round | 31/03/2021 | Jaguares de Córdoba | - | Atlético Junior | 0:2 | ||||
| 17. Round | 05/04/2021 | Atlético Junior | - | Águilas Doradas | 0:0 |
Colombia