| 1. Round | 17/07/2021 | América de Cali | - | Atlético Junior | 3:1 |  |
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| 2. Round | 25/07/2021 | Atlético Junior | - | Envigado FC | 1:0 | ||||
| 3. Round | 01/08/2021 | Independiente Medellín | - | Atlético Junior | 0:0 | ||||
| 7. Round | 29/08/2021 | Deportivo Cali | - | Atlético Junior | 1:1 | ||||
| 9. Round | 12/09/2021 | Deportivo Pereira | - | Atlético Junior | 1:1 | ||||
| 11. Round | 25/09/2021 | Águilas Doradas | - | Atlético Junior | 1:2 | ||||
| 13. Round | 12/10/2021 | Atlético Bucaramanga | - | Atlético Junior | 1:1 | ||||
| 15. Round | 24/10/2021 | Millonarios | - | Atlético Junior | 4:1 | ||||
| 17. Round | 01/11/2021 | Atlético Junior | - | Deportivo Pasto | 2:1 | ||||
| 18. Round | 07/11/2021 | Santa Fe | - | Atlético Junior | 1:1 | ||||
| 19. Round | 18/11/2021 | Atlético Junior | - | La Equidad | 1:0 |
Colombia