| 1. Round | 13/09/2021 | Liverpool | - | Deportivo Maldonado | 1:0 | ||||
| 2. Round | 19/09/2021 | Liverpool | - | River Plate | 3:1 |  |
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| 3. Round | 25/09/2021 | Cerro Largo | - | Liverpool | 3:0 | ||||
| 4. Round | 03/10/2021 | Liverpool | - | Progreso | 0:1 | ||||
| 5. Round | 10/10/2021 | Sud América | - | Liverpool | 0:1 | ||||
| 6. Round | 16/10/2021 | Liverpool | - | Plaza Colonia | 0:1 | |
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| 7. Round | 20/10/2021 | Fénix | - | Liverpool | 1:1 |  |
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| 9. Round | 29/10/2021 | Montevideo Wanderers | - | Liverpool | 1:0 | ||||
| 10. Round | 03/11/2021 | Liverpool | - | Rentistas | 0:1 | |
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| 11. Round | 07/11/2021 | Peñarol | - | Liverpool | 1:0 | ||||
| 12. Round | 13/11/2021 | Liverpool | - | Montevideo City Torque | 1:3 | ||||
| 13. Round | 19/11/2021 | Villa Española | - | Liverpool | 0:3 | ||||
| 14. Round | 26/11/2021 | Liverpool | - | Nacional | 2:2 | ||||
| 15. Round | 06/12/2021 | Cerrito | - | Liverpool | 2:1 | |
Uruguay
Italy