| 1. Round | 24/07/2022 | RSC Anderlecht | - | KV Oostende | 2:0 |  |
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| 4. Round | 12/08/2022 | KV Oostende | - | KAA Gent | 1:3 | ||||
| 5. Round | 20/08/2022 | KV Oostende | - | Sint-Truidense VV | 0:1 | ||||
| 6. Round | 27/08/2022 | Oud-Heverlee Leuven | - | KV Oostende | 2:1 | ||||
| 7. Round | 03/09/2022 | Standard Liège | - | KV Oostende | 1:0 | ||||
| 9. Round | 17/09/2022 | Cercle Brugge | - | KV Oostende | 2:2 | ||||
| 11. Round | 08/10/2022 | RFC Seraing | - | KV Oostende | 1:1 | ||||
| 12. Round | 16/10/2022 | KV Oostende | - | Union Saint-Gilloise | 1:6 | ||||
| 14. Round | 23/10/2022 | KV Oostende | - | SV Zulte Waregem | 2:1 | ||||
| 15. Round | 29/10/2022 | Club Brugge KV | - | KV Oostende | 4:2 |  |
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| 16. Round | 06/11/2022 | KV Oostende | - | KV Kortrijk | 3:1 | ||||
| 17. Round | 12/11/2022 | KVC Westerlo | - | KV Oostende | 6:0 | ||||
| 30. Round | 18/03/2023 | KV Oostende | - | KVC Westerlo | 1:2 |
Cyprus
Congo