| 2. Round | 22/08/2021 | Hibernians FC | - | Gudja United | 2:1 | ||||
| 7. Round | 23/10/2021 | Gudja United | - | Hamrun Spartans | 1:3 |  |
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| 8. Round | 31/10/2021 | Balzan FC | - | Gudja United | 1:0 | ||||
| 9. Round | 20/11/2021 | Gudja United | - | Floriana FC | 0:1 | |
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| 10. Round | 28/11/2021 | Gżira United | - | Gudja United | 3:2 | ||||
| 11. Round | 04/12/2021 | Mosta FC | - | Gudja United | 0:3 | ||||
| 12. Round | 13/12/2021 | Sirens FC | - | Gudja United | 0:0 |  |
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| 16. Round | 30/01/2022 | Valletta FC | - | Gudja United | 1:3 | ||||
| 18. Round | 13/02/2022 | Hamrun Spartans | - | Gudja United | 0:1 | |
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| 19. Round | 19/02/2022 | Gudja United | - | Balzan FC | 1:0 | ||||
| 20. Round | 26/02/2022 | Floriana FC | - | Gudja United | 2:0 | ||||
| 22. Round | 12/03/2022 | Gudja United | - | Mosta FC | 1:0 |
Colombia