| 1. Round | 22/07/2012 | Santos Laguna | - | Club San Luis | 2:1 | ||||
| 2. Round | 29/07/2012 | Deportivo Guadalajara | - | Santos Laguna | 0:1 | ||||
| 3. Round | 04/08/2012 | Santos Laguna | - | Puebla FC | 2:2 | ||||
| 4. Round | 11/08/2012 | Club León | - | Santos Laguna | 3:0 |  |
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| 5. Round | 19/08/2012 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 6. Round | 26/08/2012 | CF Pachuca | - | Santos Laguna | 0:0 | ||||
| 7. Round | 02/09/2012 | Santos Laguna | - | UANL Tigres | 3:1 | ||||
| 8. Round | 15/09/2012 | CF América | - | Santos Laguna | 2:0 | ||||
| 9. Round | 23/09/2012 | Santos Laguna | - | Jaguares Chiapas | 0:0 | ||||
| 12. Round | 07/10/2012 | Gallos Blancos (old) | - | Santos Laguna | 1:1 | ||||
| 15. Round | 28/10/2012 | CF Monterrey | - | Santos Laguna | 3:2 | |
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| 16. Round | 03/11/2012 | Santos Laguna | - | Cruz Azul | 2:1 | |
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| 17. Round | 10/11/2012 | Monarcas Morelia | - | Santos Laguna | 2:0 | |
Panama
Mexico