| 11. Round | 03/04/2022 | Atlético Huila | - | Deportes Quindío | 0:0 |  |
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| 12. Round | 12/04/2022 | Deportes Quindío | - | Real Cartagena | 5:0 |  |
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| 13. Round | 16/04/2022 | Real Santander | - | Deportes Quindío | 0:1 | |
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| 14. Round | 23/04/2022 | Deportes Quindío | - | Atlético FC | 1:0 | ||||
| 15. Round | 04/05/2022 | Leones FC | - | Deportes Quindío | 0:0 |
Colombia