| 2. Round | 30/01/2023 | Atlético Junior | - | Independiente Medellín | 1:1 |  |
 |
||
| 3. Round | 04/02/2023 | Independiente Medellín | - | Santa Fe | 1:1 | ||||
| 4. Round | 11/02/2023 | Envigado FC | - | Independiente Medellín | 2:1 | ||||
| 1. Round | 16/02/2023 | La Equidad | - | Independiente Medellín | 2:1 | ||||
| 5. Round | 18/02/2023 | Independiente Medellín | - | América de Cali | 0:1 | ||||
| 6. Round | 27/02/2023 | Alianza Petrolera | - | Independiente Medellín | 0:1 | |
|||
| 9. Round | 20/03/2023 | Independiente Medellín | - | Jaguares de Córdoba | 1:0 | ||||
| 10. Round | 25/03/2023 | Atlético Nacional | - | Independiente Medellín | 1:1 | ||||
| 11. Round | 01/04/2023 | Independiente Medellín | - | Deportes Tolima | 1:1 | ||||
| 12. Round | 09/04/2023 | Millonarios | - | Independiente Medellín | 2:1 | ||||
| 13. Round | 13/04/2023 | Independiente Medellín | - | Deportivo Cali | 3:0 | |
|||
| 14. Round | 16/04/2023 | Atlético Bucaramanga | - | Independiente Medellín | 1:2 | ||||
| 16. Round | 26/04/2023 | Atlético Huila | - | Independiente Medellín | 2:3 | |
|||
| 17. Round | 30/04/2023 | Independiente Medellín | - | Atlético Nacional | 1:3 |
Colombia