| 1. Round | 12/01/2021 | CF Pachuca | - | FC Juárez | 1:1 | ||||
| 2. Round | 19/01/2021 | Club León | - | CF Pachuca | 0:0 | ||||
| 3. Round | 26/01/2021 | CF Pachuca | - | Cruz Azul | 0:1 | ||||
| 4. Round | 30/01/2021 | Mazatlán FC | - | CF Pachuca | 1:0 | ||||
| 5. Round | 05/02/2021 | Gallos Blancos | - | CF Pachuca | 3:1 | ||||
| 6. Round | 16/02/2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 | ||||
| 9. Round | 05/03/2021 | Club Necaxa | - | CF Pachuca | 2:2 | ||||
| 10. Round | 09/03/2021 | CF Pachuca | - | Club Tijuana | 2:1 | ||||
| 11. Round | 14/03/2021 | Deportivo Toluca | - | CF Pachuca | 0:2 |  |
|||
| 12. Round | 19/03/2021 | CF Pachuca | - | UANL Tigres | 1:0 | ||||
| 13. Round | 04/04/2021 | Pumas UNAM | - | CF Pachuca | 2:2 | |
|||
| 14. Round | 13/04/2021 | CF Pachuca | - | Puebla FC | 1:3 | ||||
| 15. Round | 19/04/2021 | CF Monterrey | - | CF Pachuca | 0:1 | ||||
| 16. Round | 27/04/2021 | CF Pachuca | - | Santos Laguna | 1:0 | ||||
| 17. Round | 30/04/2021 | Atlético San Luis | - | CF Pachuca | 1:5 |
Colombia