| 3. Round | 22/07/2023 | Tacuary | - | Guaraní | 0:1 | ||||
| 4. Round | 29/07/2023 | Guaraní | - | Club Nacional | 1:1 | ||||
| 5. Round | 06/08/2023 | Club Olimpia | - | Guaraní | 5:3 | ||||
| 6. Round | 13/08/2023 | Guaireña FC | - | Guaraní | 2:1 | ||||
| 8. Round | 28/08/2023 | General Caballero DJLM | - | Guaraní | 0:1 |  |
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| 9. Round | 03/09/2023 | Guaraní | - | Resistencia SC | 3:2 | ||||
| 10. Round | 09/09/2023 | Sportivo Trinidense | - | Guaraní | 0:0 | ||||
| 11. Round | 18/09/2023 | Guaraní | - | Cerro Porteño | 1:0 | ||||
| 12. Round | 24/09/2023 | Guaraní | - | Sportivo Luqueño | 2:1 | ||||
| 13. Round | 02/10/2023 | Libertad | - | Guaraní | 0:0 | ||||
| 14. Round | 09/10/2023 | Guaraní | - | Tacuary | 2:0 | ||||
| 15. Round | 18/10/2023 | Club Nacional | - | Guaraní | 4:0 | ||||
| 16. Round | 25/10/2023 | Guaraní | - | Club Olimpia | 0:1 | |
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| 17. Round | 29/10/2023 | Guaraní | - | Guaireña FC | 0:0 | ||||
| 19. Round | 05/11/2023 | Guaraní | - | General Caballero DJLM | 2:0 | |
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| 22. Round | 01/12/2023 | Cerro Porteño | - | Guaraní | 4:0 |
Argentina