| 6. Round | 23/08/2018 | Lobos BUAP | - | CF Monterrey | 1:2 |  |
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| 7. Round | 26/08/2018 | Gallos Blancos | - | Lobos BUAP | 2:0 | |
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| 8. Round | 02/09/2018 | Lobos BUAP | - | CF América | 0:2 | ||||
| 9. Round | 16/09/2018 | Pumas UNAM | - | Lobos BUAP | 4:2 | |
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| 10. Round | 23/09/2018 | Club León | - | Lobos BUAP | 0:1 | |
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| 12. Round | 08/10/2018 | Puebla FC | - | Lobos BUAP | 2:2 | ||||
| 14. Round | 28/10/2018 | UANL Tigres | - | Lobos BUAP | 2:2 | ||||
| 15. Round | 04/11/2018 | Lobos BUAP | - | Club Tijuana | 3:1 | ||||
| 16. Round | 10/11/2018 | Cruz Azul | - | Lobos BUAP | 2:1 | |
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| 17. Round | 25/11/2018 | Lobos BUAP | - | Deportivo Toluca | 2:0 |
Honduras