| 1. Round | 06/01/2019 | Lobos BUAP | - | Santos Laguna | 2:0 | ||||
| 2. Round | 12/01/2019 | CD Veracruz | - | Lobos BUAP | 0:1 |  |
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| 3. Round | 20/01/2019 | Lobos BUAP | - | Club Necaxa | 2:3 | ||||
| 4. Round | 26/01/2019 | Atlas Guadalajara | - | Lobos BUAP | 3:1 | ||||
| 5. Round | 03/02/2019 | Lobos BUAP | - | CF Pachuca | 1:1 | ||||
| 6. Round | 09/02/2019 | CF Monterrey | - | Lobos BUAP | 4:0 | ||||
| 7. Round | 17/02/2019 | Lobos BUAP | - | Gallos Blancos | 3:1 | ||||
| 9. Round | 03/03/2019 | Lobos BUAP | - | Pumas UNAM | 2:1 | ||||
| 10. Round | 10/03/2019 | Lobos BUAP | - | Club León | 0:1 | ||||
| 11. Round | 16/03/2019 | Monarcas Morelia | - | Lobos BUAP | 1:1 | ||||
| 12. Round | 31/03/2019 | Lobos BUAP | - | Puebla FC | 0:4 | ||||
| 14. Round | 14/04/2019 | Lobos BUAP | - | UANL Tigres | 0:3 | ||||
| 15. Round | 20/04/2019 | Club Tijuana | - | Lobos BUAP | 1:2 | ||||
| 16. Round | 28/04/2019 | Lobos BUAP | - | Cruz Azul | 1:4 |
Honduras