| 1. Round | 23/07/2017 | UANL Tigres | - | Puebla FC | 5:0 | ||||
| 2. Round | 29/07/2017 | Puebla FC | - | Monarcas Morelia | 1:1 | ||||
| 3. Round | 07/08/2017 | CD Veracruz | - | Puebla FC | 2:0 | ||||
| 4. Round | 12/08/2017 | Puebla FC | - | Club Tijuana | 1:1 | ||||
| 5. Round | 20/08/2017 | Deportivo Guadalajara | - | Puebla FC | 0:1 | ||||
| 6. Round | 24/08/2017 | Puebla FC | - | Club León | 0:1 | ||||
| 7. Round | 27/08/2017 | Deportivo Toluca | - | Puebla FC | 2:1 |  |
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| 8. Round | 09/09/2017 | Puebla FC | - | Cruz Azul | 0:0 | ||||
| 11. Round | 27/09/2017 | Puebla FC | - | Atlas Guadalajara | 1:2 | ||||
| 12. Round | 02/10/2017 | Santos Laguna | - | Puebla FC | 0:0 | ||||
| 13. Round | 14/10/2017 | Puebla FC | - | Gallos Blancos | 2:2 | ||||
| 16. Round | 05/11/2017 | CF América | - | Puebla FC | 1:1 | |
Colombia