| 1. Round | 17/07/2021 | América de Cali | - | Atlético Junior | 3:1 | ||||
| 10. Round | 19/09/2021 | Atlético Junior | - | Atlético Nacional | 1:3 | ||||
| 14. Round | 18/10/2021 | Atlético Junior | - | Jaguares de Córdoba | 2:1 | ||||
| 17. Round | 01/11/2021 | Atlético Junior | - | Deportivo Pasto | 2:1 | ||||
| 18. Round | 07/11/2021 | Santa Fe | - | Atlético Junior | 1:1 |
Colombia