| 5. Round | 14/08/2022 | Alianza | - | Plaza Amador | 1:3 |  |
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| 6. Round | 21/08/2022 | Veraguas United | - | Alianza | 0:1 | ||||
| 7. Round | 29/08/2022 | San Francisco FC | - | Alianza | 0:1 | ||||
| 8. Round | 04/09/2022 | Alianza | - | Herrera FC | 1:1 | ||||
| 10. Round | 18/09/2022 | Alianza | - | Independiente de La Chorrera | 0:1 | ||||
| 12. Round | 28/09/2022 | Alianza | - | Sporting San Miguelito | 1:0 |
Panama