| 2. Round | 27/01/2022 | Atlético Nacional | - | Atlético Junior | 3:1 |  |
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| 3. Round | 29/01/2022 | Atlético Junior | - | La Equidad | 1:0 | ||||
| 10. Round | 05/03/2022 | Atlético Junior | - | Unión Magdalena | 3:1 | ||||
| 11. Round | 20/03/2022 | Deportivo Pereira | - | Atlético Junior | 1:0 | ||||
| 17. Round | 24/04/2022 | Unión Magdalena | - | Atlético Junior | 0:3 dec. | ||||
| 18. Round | 02/05/2022 | Atlético Junior | - | Envigado FC | 4:0 | |
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| 19. Round | 08/05/2022 | Cortuluá | - | Atlético Junior | 1:0 | ||||
| 20. Round | 15/05/2022 | Atlético Junior | - | Jaguares de Córdoba | 2:4 | |
Colombia