| 1. Round | 19/09/2021 | SP Tre Penne | - | SS Virtus | 2:0 | ||||
| 2. Round | 24/09/2021 | SS Virtus | - | SS Cosmos | 2:0 | ||||
| 3. Round | 02/10/2021 | SC Faetano | - | SS Virtus | 1:2 | ||||
| 4. Round | 16/10/2021 | SS Virtus | - | FC Domagnano | 1:2 |  |
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| 6. Round | 23/10/2021 | SS Virtus | - | SP La Fiorita | 0:0 | ||||
| 7. Round | 31/10/2021 | SS Virtus | - | SS Folgore/Falciano | 1:0 | ||||
| 9. Round | 21/11/2021 | SS Virtus | - | AC Libertas | 0:1 | ||||
| 10. Round | 28/11/2021 | AC Juvenes/Dogana | - | SS Virtus | 1:2 | ||||
| 11. Round | 04/12/2021 | SS Virtus | - | FC Fiorentino | 2:1 | ||||
| 12. Round | 11/12/2021 | SS Pennarossa | - | SS Virtus | 0:1 | ||||
| 13. Round | 18/12/2021 | SS Virtus | - | SP Cailungo | 0:0 | |
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| 24. Round | 05/03/2022 | AC Libertas | - | SS Virtus | 0:3 | ||||
| 27. Round | 20/03/2022 | SS Virtus | - | SS Pennarossa | 0:2 | ||||
| 16. Round | 03/04/2022 | SS Virtus | - | SP Tre Penne | 2:1 | ||||
| 17. Round | 06/04/2022 | SS Cosmos | - | SS Virtus | 0:2 | ||||
| 28. Round | 10/04/2022 | SP Cailungo | - | SS Virtus | 0:2 | |
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| 30. Round | 21/04/2022 | SS Virtus | - | SS Murata | 1:0 |
Italy