| 1. Round | 12/02/2021 | Estudiantes II | - | River Plate II | 1:3 | ||||
| 2. Round | 19/02/2021 | River Plate II | - | Rosario Central II | 1:1 | ||||
| 3. Round | 26/02/2021 | Platense II | - | River Plate II | 1:2 |  |
|||
| 4. Round | 05/03/2021 | River Plate II | - | Argentinos Juniors II | 1:0 | |
|||
| 5. Round | 12/03/2021 | Boca Juniors II | - | River Plate II | 0:1 | |
|||
| 6. Round | 19/03/2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 7. Round | 29/03/2021 | River Plate II | - | Racing Club II | 1:0 | ||||
| 8. Round | 02/04/2021 | Arsenal de Sarandí II | - | River Plate II | 1:1 | |
|||
| 9. Round | 09/04/2021 | River Plate II | - | Colón de Santa Fe II | 7:0 | |
|||
| 10. Round | 16/04/2021 | Central Córdoba SdE II | - | River Plate II | 1:2 | |
|||
| 11. Round | 23/04/2021 | River Plate II | - | San Lorenzo II | 2:1 | ||||
| 12. Round | 30/04/2021 | Banfield II | - | River Plate II | 1:2 |
Colombia