| 5. Round | 06/08/2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 8. Round | 23/08/2021 | River Plate II | - | Aldosivi II | 3:0 |  |
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| 16. Round | 15/10/2021 | River Plate II | - | San Lorenzo II | 1:3 | ||||
| 17. Round | 20/10/2021 | Talleres de Córdoba II | - | River Plate II | 1:0 | ||||
| 18. Round | 26/10/2021 | River Plate II | - | Argentinos Juniors II | 0:3 | ||||
| 19. Round | 31/10/2021 | Estudiantes II | - | River Plate II | 0:0 | ||||
| 20. Round | 05/11/2021 | River Plate II | - | Patronato de Paraná II | 2:0 | ||||
| 21. Round | 19/11/2021 | Platense II | - | River Plate II | 5:2 | |
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| 22. Round | 23/11/2021 | River Plate II | - | Racing Club II | 1:2 | ||||
| 23. Round | 28/11/2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Round | 03/12/2021 | River Plate II | - | Defensa y Justicia II | 2:1 | |
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| 25. Round | 10/12/2021 | Atlético Tucumán II | - | River Plate II | 1:1 | |
Colombia