| 1. Round | 22/08/2020 | Sepsi OSK | - | CS Universitatea Craiova | 0:1 | ||||
| 2. Round | 29/08/2020 | CFR Cluj | - | Sepsi OSK | 0:0 | ||||
| 3. Round | 13/09/2020 | Astra Giurgiu | - | Sepsi OSK | 2:2 | ||||
| 4. Round | 19/09/2020 | Sepsi OSK | - | FC Viitorul Constanța | 1:1 | ||||
| 5. Round | 25/09/2020 | FC Voluntari | - | Sepsi OSK | 1:2 |  |
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| 6. Round | 03/10/2020 | Sepsi OSK | - | Argeș Pitești | 1:0 | ||||
| 7. Round | 17/10/2020 | FC Politehnica Iași | - | Sepsi OSK | 1:4 | ||||
| 9. Round | 31/10/2020 | Academica Clinceni | - | Sepsi OSK | 2:0 | ||||
| 11. Round | 23/11/2020 | Chindia Târgoviște | - | Sepsi OSK | 1:2 |  |
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| 12. Round | 05/12/2020 | Sepsi OSK | - | FC Botoşani | 2:2 | |
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| 14. Round | 17/12/2020 | Sepsi OSK | - | UTA Arad | 3:0 | ||||
| 15. Round | 21/12/2020 | FCSB | - | Sepsi OSK | 1:1 | ||||
| 18. Round | 23/01/2021 | Sepsi OSK | - | Astra Giurgiu | 4:1 | ||||
| 19. Round | 26/01/2021 | FC Viitorul Constanța | - | Sepsi OSK | 3:3 | ||||
| 23. Round | 13/02/2021 | Dinamo Bucureşti | - | Sepsi OSK | 0:0 | ||||
| 21. Round | 16/02/2021 | Argeș Pitești | - | Sepsi OSK | 1:1 | ||||
| 26. Round | 05/03/2021 | Sepsi OSK | - | Chindia Târgoviște | 0:1 |
Romania