| 2. Round | 12/09/2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 | ||||
| 3. Round | 20/09/2021 | Omonia Nikosia | - | Doxa Katokopias | 2:1 |  |
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| 4. Round | 26/09/2021 | Omonia Nikosia | - | Paphos FC | 1:1 | ||||
| 6. Round | 17/10/2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | |
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| 7. Round | 25/10/2021 | PAEEK | - | Omonia Nikosia | 1:0 | ||||
| 8. Round | 29/10/2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 9. Round | 07/11/2021 | Ethnikos Achna | - | Omonia Nikosia | 0:2 | ||||
| 13. Round | 13/12/2021 | Omonia Nikosia | - | AEK Larnaca | 1:1 | ||||
| 14. Round | 19/12/2021 | Doxa Katokopias | - | Omonia Nikosia | 2:1 | ||||
| 1. Round | 22/12/2021 | Omonia Nikosia | - | AEL Limassol | 1:0 | ||||
| 19. Round | 29/01/2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 20. Round | 07/02/2022 | Omonia Nikosia | - | Ethnikos Achna | 0:2 | ||||
| 21. Round | 16/02/2022 | Aris Limassol | - | Omonia Nikosia | 0:2 | |
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| 22. Round | 25/02/2022 | Omonia Nikosia | - | APOEL Nikosia | 2:4 |
France