1. Round | 25/01/2021 | Club Deportivo Ocotal | - | Real Estelí FC | 0:1 | ||||
3. Round | 01/02/2021 | Real Madriz | - | Real Estelí FC | 0:1 | ||||
4. Round | 05/02/2021 | Juventus Managua | - | Real Estelí FC | 0:1 | ||||
5. Round | 08/02/2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | ||||
8. Round | 18/02/2021 | Real Estelí FC | - | Junior Managua | 7:0 | ||||
9. Round | 01/03/2021 | Real Estelí FC | - | Managua FC | 1:1 | ||||
10. Round | 07/03/2021 | Real Estelí FC | - | Club Deportivo Ocotal | 1:1 | ||||
12. Round | 01/04/2021 | Real Estelí FC | - | Real Madriz | 0:3 dec. | ||||
14. Round | 20/04/2021 | Real Estelí FC | - | ART Municipal Jalapa | 1:0 | ||||
17. Round | 02/05/2021 | Junior Managua | - | Real Estelí FC | 0:2 | ||||
18. Round | 07/05/2021 | Managua FC | - | Real Estelí FC | 1:0 |