| 1. Round | 02/08/2020 | CD Walter Ferretti | - | Real Madriz | 3:1 | ||||
| 2. Round | 09/08/2020 | Real Madriz | - | Diriangén FC | 1:1 |  |
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| 3. Round | 13/08/2020 | Real Estelí FC | - | Real Madriz | 2:0 | ||||
| 4. Round | 16/08/2020 | Real Madriz | - | Managua FC | 0:2 | ||||
| 5. Round | 24/08/2020 | Club Deportivo Ocotal | - | Real Madriz | 1:1 | ||||
| 6. Round | 31/08/2020 | Real Madriz | - | Chinandega | 0:1 | ||||
| 7. Round | 06/09/2020 | Real Madriz | - | Junior Managua | 1:1 | |
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| 8. Round | 14/09/2020 | Juventus Managua | - | Real Madriz | 1:0 | ||||
| 9. Round | 21/09/2020 | Real Madriz | - | ART Municipal Jalapa | 3:0 | |
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| 10. Round | 28/09/2020 | Real Madriz | - | CD Walter Ferretti | 2:2 | ||||
| 11. Round | 01/10/2020 | Diriangén FC | - | Real Madriz | 3:1 | |
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| 12. Round | 19/10/2020 | Real Madriz | - | Real Estelí FC | 1:0 | ||||
| 13. Round | 26/10/2020 | Managua FC | - | Real Madriz | 0:1 | ||||
| 14. Round | 30/10/2020 | Real Madriz | - | Club Deportivo Ocotal | 0:1 | ||||
| 15. Round | 01/11/2020 | Chinandega | - | Real Madriz | 1:1 | |
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| 17. Round | 15/11/2020 | Real Madriz | - | Juventus Managua | 1:1 | |
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| 18. Round | 20/11/2020 | ART Municipal Jalapa | - | Real Madriz | 2:1 |
Colombia