| Group C | 15/09/2016 | RSC Anderlecht | - | Gabala FK | 3:1 | ||||
| Group C | 29/09/2016 | AS Saint-Étienne | - | RSC Anderlecht | 1:1 | ||||
| Group C | 20/10/2016 | 1. FSV Mainz 05 | - | RSC Anderlecht | 1:1 | ||||
| Group C | 03/11/2016 | RSC Anderlecht | - | 1. FSV Mainz 05 | 6:1 |  |
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| Group C | 24/11/2016 | Gabala FK | - | RSC Anderlecht | 1:3 | ||||
| Group C | 08/12/2016 | RSC Anderlecht | - | AS Saint-Étienne | 2:3 | ||||
| Round of 32 | 16/02/2017 | RSC Anderlecht | - | Zenit St. Petersburg | 2:0 |  |
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| Round of 32 | 23/02/2017 | Zenit St. Petersburg | - | RSC Anderlecht | 3:1 | |
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| Round of 16 | 09/03/2017 | APOEL Nikosia | - | RSC Anderlecht | 0:1 | ||||
| Round of 16 | 16/03/2017 | RSC Anderlecht | - | APOEL Nikosia | 1:0 | |
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| Quarter-finals | 13/04/2017 | RSC Anderlecht | - | Manchester United | 1:1 | ||||
| Quarter-finals | 20/04/2017 | Manchester United | - | RSC Anderlecht | 2:1 aet |
Ghana