| 1. Round | 20/02/2021 | San Francisco FC | - | Atlético Chiriquí | 4:4 | ||||
| 2. Round | 28/02/2021 | Atlético Chiriquí | - | Herrera FC | 0:2 | ||||
| 5. Round | 16/03/2021 | Atlético Chiriquí | - | Independiente de La Chorrera | 2:1 |  |
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| 6. Round | 20/03/2021 | Atlético Chiriquí | - | Alianza | 2:0 | ||||
| 7. Round | 23/03/2021 | Tauro FC | - | Atlético Chiriquí | 2:0 | ||||
| 11. Round | 17/04/2021 | Sporting San Miguelito | - | Atlético Chiriquí | 2:1 | ||||
| 12. Round | 21/04/2021 | Atlético Chiriquí | - | San Francisco FC | 3:0 | |
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| 13. Round | 25/04/2021 | Herrera FC | - | Atlético Chiriquí | 3:0 | ||||
| 14. Round | 28/04/2021 | UD Universitario | - | Atlético Chiriquí | 2:1 | ||||
| 15. Round | 03/05/2021 | Atlético Chiriquí | - | Veraguas Club Deportivo | 0:1 | ||||
| 16. Round | 08/05/2021 | Independiente de La Chorrera | - | Atlético Chiriquí | 1:2 |
Panama