2. Round | 10/08/2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
3. Round | 15/08/2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
5. Round | 29/08/2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
6. Round | 03/09/2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
7. Round | 12/09/2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 |