| 1. Round | 21/08/2021 | RSC Anderlecht [U18] | - | KV Mechelen [U18] | 2:1 | ||||
| 2. Round | 28/08/2021 | KV Mechelen [U18] | - | Sint-Truidense VV [U18] | 3:3 | ||||
| 4. Round | 11/09/2021 | KAA Gent [U18] | - | KV Mechelen [U18] | 1:3 | ||||
| 6. Round | 25/09/2021 | Sporting Charleroi [U18] | - | KV Mechelen [U18] | 2:1 | ||||
| 7. Round | 02/10/2021 | KV Mechelen [U18] | - | KRC Genk [U18] | 2:3 |  |
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| 8. Round | 09/10/2021 | SV Zulte Waregem [U18] | - | KV Mechelen [U18] | 3:1 | ||||
| 9. Round | 16/10/2021 | KV Mechelen [U18] | - | Royal Antwerp FC [U18] | 1:0 | ||||
| 10. Round | 23/10/2021 | KVC Westerlo [U18] | - | KV Mechelen [U18] | 0:5 | ||||
| 3. Round | 27/10/2021 | Club Brugge KV [U18] | - | KV Mechelen [U18] | 8:0 | ||||
| 13. Round | 20/11/2021 | KV Mechelen [U18] | - | Oud-Heverlee Leuven [U18] | 2:1 | ||||
| 14. Round | 27/11/2021 | KV Mechelen [U18] | - | RSC Anderlecht [U18] | 2:0 | ||||
| 16. Round | 22/01/2022 | KV Mechelen [U18] | - | Club Brugge KV [U18] | 1:4 | ||||
| 17. Round | 29/01/2022 | KV Mechelen [U18] | - | Sporting Charleroi [U18] | 0:2 | ||||
| 12. Round | 26/02/2022 | Standard Liège [U18] | - | KV Mechelen [U18] | 1:1 | ||||
| 23. Round | 19/03/2022 | KV Mechelen [U18] | - | KVC Westerlo [U18] | 3:1 |
Belgium
Senegal