| 1. Round | 23/07/2021 | FC Fredericia | - | Hobro IK | 2:0 | ||||
| 2. Round | 30/07/2021 | Hobro IK | - | Vendsyssel FF | 1:1 |  |
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| 4. Round | 14/08/2021 | Hobro IK | - | Lyngby BK | 1:4 | ||||
| 5. Round | 18/08/2021 | Jammerbugt FC | - | Hobro IK | 1:1 | ||||
| 6. Round | 23/08/2021 | Hobro IK | - | Nykøbing FC | 1:2 | ||||
| 7. Round | 30/08/2021 | Hvidovre IF | - | Hobro IK | 2:2 | ||||
| 8. Round | 10/09/2021 | Esbjerg fB | - | Hobro IK | 2:1 | ||||
| 9. Round | 18/09/2021 | Hobro IK | - | AC Horsens | 0:3 | ||||
| 17. Round | 28/11/2021 | AC Horsens | - | Hobro IK | 2:1 |  |
Denmark