| 1. Round | 04/09/2021 | PSIS Semarang | - | Persela Lamongan | 1:0 | ||||
| 2. Round | 12/09/2021 | Persija Jakarta | - | PSIS Semarang | 2:2 | ||||
| 3. Round | 18/09/2021 | PSIS Semarang | - | Persiraja Banda Aceh | 3:1 | ||||
| 4. Round | 25/09/2021 | Arema Cronus FC | - | PSIS Semarang | 0:0 | ||||
| 5. Round | 29/09/2021 | PSIS Semarang | - | Madura United | 0:0 | ||||
| 6. Round | 03/10/2021 | Persebaya Surabaya | - | PSIS Semarang | 2:3 |  |
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| 7. Round | 15/10/2021 | PSIS Semarang | - | Persik Kediri | 3:0 |  |
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| 8. Round | 20/10/2021 | PS Barito Putera | - | PSIS Semarang | 0:1 | ||||
| 9. Round | 26/10/2021 | PSIS Semarang | - | Persib Bandung | 0:1 | ||||
| 10. Round | 31/10/2021 | Bali United | - | PSIS Semarang | 0:0 | ||||
| 11. Round | 06/11/2021 | PSIS Semarang | - | Borneo FC | 0:1 | ||||
| 12. Round | 18/11/2021 | Persikabo 1973 | - | PSIS Semarang | 2:2 | ||||
| 13. Round | 22/11/2021 | PSIS Semarang | - | PSM Makassar | 1:0 | ||||
| 17. Round | 11/12/2021 | Persipura Jayapura | - | PSIS Semarang | 2:1 | ||||
| 29. Round | 06/03/2022 | PSM Makassar | - | PSIS Semarang | 2:1 | ||||
| 34. Round | 29/03/2022 | Persela Lamongan | - | PSIS Semarang | 1:2 |
Indonesia