| 1. Round | 12/12/2020 | Al Mokawloon | - | Zamalek | 0:2 | ||||
| 2. Round | 17/12/2020 | Pyramids FC | - | Zamalek | 1:1 | ||||
| 3. Round | 28/12/2020 | Smouha Sporting Club | - | Zamalek | 0:2 | ||||
| 5. Round | 02/01/2021 | ENPPI | - | Zamalek | 1:2 | ||||
| 6. Round | 09/01/2021 | Zamalek | - | Tala'ea El Gaish SC | 3:0 | ||||
| 7. Round | 12/01/2021 | Al Masry Club | - | Zamalek | 0:1 | ||||
| 8. Round | 19/01/2021 | Zamalek | - | El Gouna | 1:0 | ||||
| 9. Round | 23/01/2021 | Aswan SC | - | Zamalek | 0:0 | ||||
| 10. Round | 28/01/2021 | Zamalek | - | Misr lel-Maqasah SC | 4:1 | ||||
| 11. Round | 02/02/2021 | Ghazl Al Mehalla | - | Zamalek | 2:1 | ||||
| 12. Round | 07/02/2021 | Zamalek | - | Ittihad El Iskandary | 2:0 | ||||
| 13. Round | 17/02/2021 | Zamalek | - | Ismaily | 2:1 | ||||
| 16. Round | 22/04/2021 | El Entag El Harby | - | Zamalek | 0:2 | ||||
| 17. Round | 26/04/2021 | Zamalek | - | National Bank SC | 4:1 | ||||
| 31. Round | 17/08/2021 | Zamalek | - | Wadi Degla SC | 1:0 | ||||
| 32. Round | 20/08/2021 | Ceramica Cleopatra | - | Zamalek | 1:2 | ||||
| 33. Round | 24/08/2021 | Zamalek | - | El Entag El Harby | 2:0 | ||||
| 34. Round | 27/08/2021 | National Bank SC | - | Zamalek | 1:1 |
Egypt