1. Round | 13/09/2021 | Progreso | - | Villa Española | 1:1 | ||||
2. Round | 18/09/2021 | Villa Española | - | Sud América | 1:2 | ||||
5. Round | 10/10/2021 | Boston River | - | Villa Española | 1:0 | ||||
7. Round | 20/10/2021 | Rentistas | - | Villa Española | 3:1 | ||||
8. Round | 23/10/2021 | Villa Española | - | Peñarol | 1:3 | ||||
10. Round | 02/11/2021 | Deportivo Maldonado | - | Villa Española | 0:1 | ||||
11. Round | 07/11/2021 | Villa Española | - | Nacional | 1:2 | ||||
13. Round | 19/11/2021 | Villa Española | - | Liverpool | 0:3 |