| 2. Round | 01/08/2021 | Orense SC | - | Delfín SC | 2:2 | ||||
| 3. Round | 09/08/2021 | Delfín SC | - | Emelec | 1:2 | ||||
| 5. Round | 23/08/2021 | Delfín SC | - | Independiente del Valle | 0:0 |  |
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| 6. Round | 31/08/2021 | Deportivo Cuenca | - | Delfín SC | 2:3 | ||||
| 7. Round | 18/09/2021 | Delfín SC | - | Aucas | 1:2 | |
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| 8. Round | 26/09/2021 | Macará | - | Delfín SC | 2:3 | ||||
| 9. Round | 05/10/2021 | Delfín SC | - | Manta | 2:1 |
Ecuador