| 1. Round | 13/01/2022 | Municipal Pérez Zeledón | - | Municipal Grecia | 1:1 | ||||
| 2. Round | 16/01/2022 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 3. Round | 22/01/2022 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 4. Round | 04/02/2022 | Municipal Pérez Zeledón | - | LD Alajuelense | 2:1 |  |
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| 5. Round | 09/02/2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:0 | ||||
| 6. Round | 13/02/2022 | Santos de Guápiles | - | Municipal Pérez Zeledón | 0:1 | ||||
| 7. Round | 20/02/2022 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:0 | ||||
| 8. Round | 26/02/2022 | Sporting FC | - | Municipal Pérez Zeledón | 1:1 | ||||
| 9. Round | 02/03/2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 | ||||
| 10. Round | 08/03/2022 | Municipal Pérez Zeledón | - | Jicaral | 2:1 |  |
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| 20. Round | 08/05/2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | ||||
| 21. Round | 11/05/2022 | Jicaral | - | Municipal Pérez Zeledón | 2:1 | ||||
| 22. Round | 15/05/2022 | Municipal Pérez Zeledón | - | CS Herediano | 2:3 |
Costa Rica