1. Round | 02/08/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 | ||||
2. Round | 08/08/2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:0 | ||||
3. Round | 15/08/2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
4. Round | 23/08/2021 | Club Deportivo Ocotal | - | Diriangén FC | 1:1 | ||||
5. Round | 29/08/2021 | Club Deportivo Ocotal | - | Real Madriz | 2:1 | ||||
7. Round | 13/09/2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 | ||||
8. Round | 20/09/2021 | Club Deportivo Ocotal | - | UNAN Managua | 1:2 | ||||
6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
9. Round | 26/09/2021 | Club Deportivo Ocotal | - | Real Estelí FC | 1:2 | ||||
10. Round | 03/10/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:0 | ||||
11. Round | 10/10/2021 | Club Deportivo Ocotal | - | CD Walter Ferretti | 3:0 | ||||
12. Round | 16/10/2021 | Club Deportivo Ocotal | - | H&H Export Sébaco | 1:1 | ||||
17. Round | 18/11/2021 | UNAN Managua | - | Club Deportivo Ocotal | 2:3 | ||||
18. Round | 22/11/2021 | Real Estelí FC | - | Club Deportivo Ocotal | 4:0 |