5. Round | 05/08/2021 | Chicago Fire | - | New York City FC | 0:0 | ||||
6. Round | 19/09/2021 | CF Montréal | - | Chicago Fire | 2:0 | ||||
6. Round | 23/09/2021 | Chicago Fire | - | New England Revolution | 2:3 | ||||
6. Round | 26/09/2021 | Chicago Fire | - | Nashville SC | 0:0 | ||||
6. Round | 30/09/2021 | Chicago Fire | - | New York City FC | 2:0 | ||||
7. Round | 03/10/2021 | Toronto FC | - | Chicago Fire | 3:1 | ||||
7. Round | 17/10/2021 | New England Revolution | - | Chicago Fire | 2:2 | ||||
7. Round | 21/10/2021 | FC Cincinnati | - | Chicago Fire | 3:4 | ||||
7. Round | 24/10/2021 | Chicago Fire | - | Real Salt Lake | 1:0 | ||||
7. Round | 28/10/2021 | New York City FC | - | Chicago Fire | 1:0 | ||||
8. Round | 07/11/2021 | Columbus Crew | - | Chicago Fire | 2:0 |