1. Round | 25/07/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
2. Round | 01/08/2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
3. Round | 08/08/2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
4. Round | 14/08/2021 | Pumas UNAM | - | Gallos Blancos | 0:0 | ||||
5. Round | 18/08/2021 | Club Necaxa | - | Pumas UNAM | 3:0 | ||||
6. Round | 22/08/2021 | Pumas UNAM | - | Puebla FC | 2:0 | ||||
7. Round | 29/08/2021 | Deportivo Toluca | - | Pumas UNAM | 2:1 | ||||
9. Round | 19/09/2021 | Mazatlán FC | - | Pumas UNAM | 2:2 |