| Qual. 1. Round | 11/09/2021 | Jwaneng Galaxy | - | DFC 8ème | 2:0 | ||||
| Qual. 1. Round | 17/09/2021 | DFC 8ème | - | Jwaneng Galaxy | 1:0 | ||||
| Qual. 2. Round | 17/10/2021 | Jwaneng Galaxy | - | Simba SC | 0:2 |  |
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| Qual. 2. Round | 24/10/2021 | Simba SC | - | Jwaneng Galaxy | 1:3 |  |
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| Group C | 12/02/2022 | Espérance de Tunis | - | Jwaneng Galaxy | 4:0 | ||||
| Group C | 19/02/2022 | Jwaneng Galaxy | - | Étoile du Sahel | 1:1 | |
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| Group C | 11/03/2022 | CR Bélouizdad | - | Jwaneng Galaxy | 4:1 | ||||
| Group C | 19/03/2022 | Jwaneng Galaxy | - | Espérance de Tunis | 0:3 | |
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| Group C | 01/04/2022 | Étoile du Sahel | - | Jwaneng Galaxy | 3:2 | |
Botswana