| 1. Round | 07/08/2021 | Châteaubriant Voltigeurs | - | Vannes OC | 1:3 | ||||
| 2. Round | 14/08/2021 | SM Caen B | - | Vannes OC | 0:0 | ||||
| 3. Round | 21/08/2021 | Vannes OC | - | US Granvillaise | 0:0 | ||||
| 4. Round | 28/08/2021 | SO Romorantin | - | Vannes OC | 1:2 | ||||
| 5. Round | 04/09/2021 | Vannes OC | - | FC Rouen 1899 | 1:2 | ||||
| 6. Round | 11/09/2021 | AS Vitré | - | Vannes OC | 0:1 | ||||
| 7. Round | 18/09/2021 | Vannes OC | - | FC Versailles | 0:1 | ||||
| 10. Round | 23/10/2021 | St-Pryvé St-Hilaire | - | Vannes OC | 1:1 | ||||
| 11. Round | 07/11/2021 | Vannes OC | - | Blois Foot 41 | 2:2 | ||||
| 12. Round | 20/11/2021 | FC Lorient B | - | Vannes OC | 1:0 |
France