| 1. Round | 19/08/2022 | Birkirkara FC | - | Sirens FC | 2:0 | ||||
| 3. Round | 03/09/2022 | Valletta FC | - | Sirens FC | 0:0 |  |
|||
| 6. Round | 09/10/2022 | Sirens FC | - | Gżira United | 0:3 | ||||
| 7. Round | 16/10/2022 | Balzan FC | - | Sirens FC | 0:0 | ||||
| 8. Round | 21/10/2022 | Sirens FC | - | Żebbuġ Rangers | 3:3 | ||||
| 9. Round | 29/10/2022 | St. Luċija FC | - | Sirens FC | 0:0 | ||||
| 10. Round | 05/11/2022 | Sirens FC | - | Gudja United | 2:0 | ||||
| 11. Round | 13/11/2022 | Marsaxlokk FC | - | Sirens FC | 1:2 | ||||
| 12. Round | 03/12/2022 | Sirens FC | - | Hibernians FC | 0:1 | ||||
| 13. Round | 10/12/2022 | Pietá Hotspurs | - | Sirens FC | 0:1 | ||||
| 14. Round | 16/12/2022 | Sirens FC | - | Birkirkara FC | 1:0 | ||||
| 15. Round | 07/01/2023 | Floriana FC | - | Sirens FC | 1:0 | ||||
| 21. Round | 04/03/2023 | Żebbuġ Rangers | - | Sirens FC | 0:1 | ||||
| 22. Round | 12/03/2023 | Sirens FC | - | St. Luċija FC | 2:1 |  |
|||
| 23. Round | 01/04/2023 | Gudja United | - | Sirens FC | 0:1 | ||||
| 24. Round | 08/04/2023 | Sirens FC | - | Marsaxlokk FC | 3:2 | ||||
| 25. Round | 15/04/2023 | Hibernians FC | - | Sirens FC | 1:1 | ||||
| 26. Round | 20/04/2023 | Sirens FC | - | Pietá Hotspurs | 0:0 |
Malta