| 1. Round | 19/09/2021 | UE Santa Coloma | - | FC Santa Coloma | 2:1 | ||||
| 2. Round | 26/09/2021 | UE Sant Julià | - | UE Santa Coloma | 1:2 | ||||
| 3. Round | 03/10/2021 | UE Santa Coloma | - | Inter Club d'Escaldes | 0:1 | ||||
| 4. Round | 17/10/2021 | Atlétic Escaldes | - | UE Santa Coloma | 0:0 | ||||
| 5. Round | 24/10/2021 | FC Ordino | - | UE Santa Coloma | 0:2 | ||||
| 6. Round | 31/10/2021 | UE Santa Coloma | - | UE Engordany | 1:0 | ||||
| 7. Round | 07/11/2021 | CE Carroi | - | UE Santa Coloma | 1:2 | ||||
| 9. Round | 28/11/2021 | UE Santa Coloma | - | UE Sant Julià | 1:1 | ||||
| 10. Round | 19/12/2021 | Inter Club d'Escaldes | - | UE Santa Coloma | 2:2 | ||||
| 11. Round | 09/01/2022 | UE Santa Coloma | - | Atlétic Escaldes | 1:3 |
Uruguay